6. What happens next?
Digestive System Exposure

Recent policy changes in regard to titanium dioxide
Water solubles, %
In a 2021, Chinese researchers examined the impact of E171 on lipid digestion and vitamin D3 bioaccessibility in a simulated human gastrointestinal tract model. They examined Vitamin D’s bioaccessibility, or the amount it was released in the gastrointestinal tract, becoming available for absorption, and found it “significantly decreased from 80% to 74%” with the addition of E171. In the experiment, E171 decreased lipid digestion dose-dependently. Researchers wrote: “The findings of this study enhance our understanding toward the potential impact of E171 on the nutritional attributes of foods for human digestion health.” The study was published in the Journal of Agricultural and Food Chemistry,
Research has shown that, when ingested as a food additive, titanium dioxide and its nanoparticles can impact, alter, and/or damage important protective bacteria in the gut, along with the metabolic pathways of gut bacteria.
Overall, Chinese anatase titanium dioxide stands out as a versatile and valuable material with a wide range of applications in various industries. Its unique properties make it a popular choice for use in pigments, sunscreen, environmental remediation, and energy conversion technologies. As research into this material continues to expand, we can expect to see even more innovative uses and advancements in the field of materials science.
Studies of titanium dioxide as a food additive suggest health dangers



lithopone 28~30% manufacturers.
From studies deemed relevant, the experts found that titanium dioxide as a food additive is poorly absorbed by the gastrointestinal tract of mice and rats, with no adverse effects observed in short-term studies in rodents receiving titanium dioxide in their diets. No observed adverse effect levels (NOAELs) of 15,000 milligrams per kilogram of bodyweight (mg/kg BW) per day and 5,000 mg/kg BW per day—the highest doses tested—were established for mice and rats, respectively.
Founded in 1902 by Henrick J. Krebs, Krebs Pigments and Chemical Company produced lithopone, a widely used white paint pigment also manufactured by DuPont. But Krebs' company had another asset of special interest to DuPont. ...
What titanium dioxide is really emblematic of ... is the failure of FDA to look back at these old decisions and ask whether its decisions that were made in this case ... 56 years ago (in the 1966 approval) still hold up, he said.
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