Overall, the Food Directorate's comprehensive review of the available science of TiO₂ as a food additive showed:

Blanc de Comines, 27 per cent zinc sulphide, 70.5 per cent barium sulphate, 2.5 per cent zinc carbonate.

Food additive nanoparticles could negatively affect your gut health, by Jillian McCarthy, Binghamton University, May 4, 2023

In terms of sustainability, the use of rutile titanium dioxide in coatings aligns with the global push towards eco-friendliness. The product is non-toxic and, when combined with solvent-free formulations, can contribute to reduced volatile organic compound (VOC) emissions, making it a safer option for both the environment and those applying the coatings.

Porcelain White, 32 per cent sulphide, 68 per cent barium sulphate.

See also

TiO₂ is typically thought of as being chemically inert, meaning it does not react with other chemicals and is, therefore, a stable substance that can be used in many different industries and for various applications.

Hemolysis was studied on suspensions of P25TiO₂NPs (0.2 mg/mL and 0.02 mg/mL), vitaminB2@P25TiO₂NPs (0.2 mg/mL and 0.02 mg/mL) and vitamin B2 (0.2 mg/mL and 0.02 mg/mL) were prepared and mixed with 500 μL of anticoagulated blood (donated by Laboratorio de Hemoderivados, UNC) in a rate of 1/10. A solution of NaCl 10% was used as the positive control and PBS as the negative control. Then, the samples were irradiated using the LED described above for 3 and 6 h to simulate the light penetration into the skin. Also, a set of samples was kept in the dark as control. Finally, the samples were centrifuged and the absorbance at 540 nm was measured in the supernatants. The experiment was reproduced twice; the standard deviation was calculated and p-value < 0.05 were considered significant.