Lithopone 30% CAS No. 1345-05-7 / Application

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A1:

A  2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

R-895 is a paint grade titanium dioxide pigment produced by the chlorination process. Recommended for use in a variety of coating applications.

There are two primary forms of titanium dioxide commercially available: anatase and rutile. The rutile form is typically used in sunscreens due to its superior ability to handle UV rays and stability in the presence of UV light. The anatase form is typically used in other types of products, such as paint. Another plus of the rutile form is that its UVA protection extends past 400 nanometers, which is the upper limit of UVA.

About CCM:

Infrared analysis showed that the characteristics bands for the bare nanoparticles are still exhibited in the vitamins@P25TiO₂NPs spectra, such as a wide peak in 450–1028 cm⁻¹ related to the stretching vibration of Ti-O-Ti and other peaks in 1630 cm⁻¹ and 3400 cm⁻¹, which represent the surface OH groups stretching. The IR spectrum of vitaminB2@P25TiO₂NPs showed signs of binding between compounds. The OH bending peak (1634 cm⁻¹) corresponding to bare nanoparticles disappeared, and the NH₂ bending band characteristic of vitamin B2 appeared (1650 cm⁻¹). The IR spectrum of vitaminC@P25TiO₂NPs also showed signs of successful functionalization. Bands at 1075 cm⁻¹; 1120 cm⁻¹; 1141 cm⁻¹ were observed, which are originated by CO-C vibrations present in the vitamin C. The intense band at 1672 cm⁻¹ is attributed to the C = O stretching in the lactone ring while the peak at 1026 cm⁻¹ is ascribed to the stretching vibration Ti-O-C. Wide bands at 3880–3600 cm⁻¹ are related to stretching vibration OH groups, but those disappear in the modified nanoparticles spectrum. These observations confirm the interactions between the P25TiO₂NPs and the vitamins [35].

Although the evidence for general toxic effects was not conclusive, on the basis of the new data and strengthened methods we could not rule out a concern for genotoxicity and consequently we could not establish a safe level for daily intake of the food additive, commented Matthew Wright, member of the EFSA's Food Additives and Flavourings Panel in a press statement.

Main products are titanium dioxide LR-982, titanium dioxide LR-108, titanium dioxide LR-996, LR-895 and other products.